Abstract

This preclinical study demonstrates that hepatic delivery of a microRNA-30c analog (C2) significantly reduces plasma cholesterol levels and atherosclerotic plaque burden in both mice and non-human primates without inducing hepatotoxicity. The C2 analog targets key regulators of hepatic lipid metabolism, offering a novel mechanism distinct from existing statin-based therapies. In murine models, C2 treatment resulted in substantial reductions in total cholesterol and LDL-C alongside decreased aortic plaque area, while liver function markers remained within normal limits. Non-human primate studies confirmed dose-dependent cholesterol lowering with an excellent safety profile. Selected as a top-3 abstract out of over 200 submissions at the American Heart Association Scientific Sessions.

About This Editorial

This editorial reexamines the pioneering contributions of Vladimir P. Demikhov, the Soviet physiologist who performed the world's first experimental heart transplant in 1946, the first heart-lung transplant, and the first experimental coronary artery bypass — yet remains largely absent from Western medical history. Demikhov's 1960 monograph became the foundational text of thoracic transplantation and directly influenced Christiaan Barnard, Norman Shumway, and Richard Lower.

Abstract

Background: Tapia's syndrome is a rare neurological condition defined by concurrent unilateral paralysis of the vagus (CN X) and hypoglossal (CN XII) nerves, most commonly reported after orotracheal intubation.

Case Presentation: A 66-year-old female presented with acute-onset dysphonia, dysphagia, and right-sided tongue deviation beginning shortly after initiating CPAP therapy with a full-face mask. Clinical examination revealed right-sided vagus and hypoglossal nerve palsies. Laryngoscopy confirmed right vocal cord paralysis. MRI and MRA excluded central pathologies. Near-complete resolution over 6 weeks with corticosteroids and speech therapy.

Conclusion: This case suggests Tapia's syndrome can occur as a rare complication of noninvasive positive-pressure ventilation — a previously unreported association.

Abstract

Background: ASH1L-related intellectual developmental disorder is an emerging neurodevelopmental syndrome with significant phenotypic heterogeneity.

Case Presentation: A 6-year-old Central Asian (Uzbek) male with global developmental delay, speech difficulties, and behavioral challenges. Whole-exome sequencing identified a novel de novo missense variant in ASH1L (c.7849G>A, p.Ala2617Thr). Mild ASD with preserved visuospatial abilities but significant language and adaptive behavior delays.

Conclusion: Expands the genotypic and phenotypic spectrum of ASH1L-related disorders and underscores the importance of whole-exome sequencing in underrepresented populations.

Summary

Retrospective cohort of 418 patients demonstrating ~26% reduction in hydromorphone PCA consumption at 12–24 hours postoperatively with erector spinae plane blocks during VATS, without significant differences in pain scores or length of stay.